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How Has Deep Brain Stimulation Benefitted Patients With Parkinson’s Disease?

How Has Deep Brain Stimulation Benefitted Patients With Parkinson’s Disease?

Sep 04, 2020

Dr. Sameer Sheth, neurosurgeon at Baylor St. Luke’s Medical Center, uses deep brain stimulation (DBS) as an alternative to medication for treating disorders such as Parkinson’s disease and essential tremor. DBS involves placing a device called a neurostimulator that sends electrical impulses through implanted electrodes to specific targets in the brain.

What Is Deep Brain Stimulation and How Does It Work?

“DBS is a therapy that we have for various neurological conditions,” said Dr. Sheth. “It's a system that you can think of like a pacemaker. But rather than being a pacemaker for the heart, it's for the brain.”

Dr. Sheth describes the brain as having many circuits that govern everything we do, including how we move.

“If the movement circuit is not working properly, we may have a movement disorder like Parkinson's,” he said. “If we can identify the circuit within the brain that is not working properly, we can use this device to reset the rhythms in the brain and restore the balance so that our movements can be better controlled or without a tremor.”

How Effective Is DBS Therapy?

Though DBS is considered an alternative, it’s a well-established, FDA-approved technique that has been used to treat Parkinson’s and essential tremor for 30+ years.

“There's been a lot of studies over the years,” said Dr. Sheth. “Randomized trials have been presented in the top medical journals that show that for the appropriately chosen patient, DBS is more effective than the best medical therapy. So, in that appropriately chosen patient, DBS can be very successful at improving tremor for essential tremor and tremor stiffness, rigidity, and those other motor symptoms of Parkinson's disease.”

One patient who has found success with DBS is Rudy Hardy.

“It’s made a profound difference in my life,” said Hardy. A professional sports photographer and professor of criminal justice, Hardy’s life was controlled by Parkinson’s. He tried medication initially, and though it seemed to work for a while, his tremors eventually worsened. Since undergoing DBS, Hardy’s symptoms are now almost completely undetectable. Watch Hardy talk about his experience with DBS below.

How Does DBS Compare to Other Methods of Treatment for Parkinson’s Disease?

As in Hardy’s case, every patient’s treatment begins with medication until it is determined that they can benefit from DBS. “Medications are always tried first. Unfortunately, we can only get so far with medications. Oftentimes, many patients try them, and they may work for a little while,” said Dr. Sheth.

“But at some point, oftentimes the medications stop working as much because the disorder tends to progress over the years. It could get worse, and the medicines may not be able to keep up. Many of the medicines themselves have their own side effects. So, you get to a point where perhaps the medicines are helping to a degree, but they're causing their own side effects, and exactly when we get to that point is when we introduce the idea of a surgical therapy like DBS.”

How Common Is DBS?

Dr. Sheth describes DBS as a very standard treatment. “These are procedures that we do week in and week out,” he said. “It's not investigational or experimental.” Around the world, more than 150,000 patients have had DBS for Parkinson's or tremor with a success rate of 95%.

“Patients need to know that there are these alternatives. They need to know that they're not necessarily stuck with these symptoms, that there may be a different way to get better control. That discussion is, of course, individual-specific, but the availability of these types of surgical treatments is important for patients to know about.”

As Houston’s leader in neurology and neurosurgery, the Neuroscience Institute at Baylor St. Luke’s Medical Center is continually working to find better treatments for neurological conditions to help patients get back their lives. Visit a neurologist to see if you are a candidate for deep brain stimulation.

Interview conducted by Ivanhoe Broadcast News.